{
  "title": "Interrupt Triage: How a 1969 Guidance Computer and a Stressed Cell Agree on What to Drop",
  "author": "Tammera Storey",
  "date": "2026-07-22",
  "url": "https://tammera-storey.4ort.net/interrupt-triage.html",
  "type": "essay",
  "tags": ["interrupt-triage", "apollo-11", "cell-biology", "stress-response", "comparative-architecture"],
  "summary": "A comparative essay on how the Apollo Guidance Computer's real-time priority scheduler and mammalian cellular stress response pathways both perform triage under resource constraints.",
  "comparison": {
    "dimensions": [
      {
        "dimension": "Scheduler",
        "agc": "15-level priority executive",
        "cell": "Phospho-proteomic cascade hierarchy"
      },
      {
        "dimension": "Deadline",
        "agc": "4 ms (guidance loop)",
        "cell": "Seconds to minutes (protein half-lives)"
      },
      {
        "dimension": "Overflow signal",
        "agc": "Alarm 1201 / 1202",
        "cell": "Apoptosis / senescence markers"
      },
      {
        "dimension": "Resource limit",
        "agc": "2 MHz clock, 24 KB ROM",
        "cell": "Finite ATP, kinase pool, ribosome capacity"
      },
      {
        "dimension": "Triage mechanism",
        "agc": "Drop lowest-priority ready task",
        "cell": "Suppress growth pathways (mTOR inhibition)"
      },
      {
        "dimension": "Failure mode",
        "agc": "Executive stall → manual override",
        "cell": "Apoptosis → tissue loss, inflammation"
      },
      {
        "dimension": "Recovery",
        "agc": "Reboot if needed; resume",
        "cell": "Autophagy clears damage; homeostasis restored"
      }
    ]
  },
  "cell_stress_priorities": [
    {"signal": "DNA damage (p53 activation)", "priority": "critical", "response": "Cell cycle arrest; repair or apoptosis"},
    {"signal": "ER stress (PERK/ATF6 activation)", "priority": "high", "response": "Unfolded protein response; translate throttle-down"},
    {"signal": "Mitochondrial dysfunction", "priority": "high", "response": "Metabolic rewiring; fission/fusion balance"},
    {"signal": "Growth factor signaling (PI3K/Akt)", "priority": "deferred", "response": "Suppressed until stress resolves"},
    {"signal": "Cytokine production", "priority": "context-dependent", "response": "Modulated; may be amplified or silenced"}
  ],
  "sources": {
    "agc_wikidata": "https://4ort.xyz/entity/apollo-guidance-computer",
    "apollo11_nasa": "https://www.nasa.gov/mission_pages/apollo/missions/apollo11.html",
    "apollo11_sil": "https://airandspace.si.edu/explore-and-learn/topics/apollo/apollo-program/landing-missions/apollo11-facts.cfm",
    "agc_source": "https://github.com/chrislgarry/Apollo-11",
    "agc_talk": "https://media.ccc.de/v/34c3-9064-the_ultimate_apollo_guidance_computer_talk"
  }
}